Cancer Metabolism Based Therapeutics Market Growth Accelerated by Increasing Investment Research and Development


 Cancer metabolism based therapeutics aims at inhibiting tumor growth by targeting metabolic pathways in cancer cells. Therapies targeting key metabolic enzymes have shown promise in preclinical studies. The global Cancer Metabolism Based Therapeutics Market is estimated to be valued at US$ 210.2 Bn in 2023 and is expected to exhibit a CAGR of 95.% over the forecast period 2023 to 2030, as highlighted in a new report published by Coherent Market Insights.


Market key trends:
Increasing investment by biopharma companies in research and development of novel cancer metabolism based drug targets is one of the major trends fueling the market growth. Many players are actively investing in exploring new pathways and validating drug targets through preclinical research. For example, in 2022 Calithera Biosciences, Inc. received $60 million funding to advance its pipeline of novel cancer metabolism modulators into clinical development. Such increased funding and collaborations between academic institutions and industry is aiding in faster translation of research into potential drug candidates, thereby accelerating the market growth over the forecast period.

Segment Analysis
The global cancer metabolism based therapeutics market is dominanted by pyruvate kinase inhibitors sub segment. Pyruvate kinase isoenzyme type M2 (PKM2) is a key driver of the Warburg effect, which is when cancer cells rely primarily on aerobic glycolysis rather than oxidative phosphorylation to generate energy. Several PKM2 inhibitors are being developed and tested in clinical trials for various cancers like solid tumors. As PKM2 expression is prevalent in most cancers, targeting this enzyme's activity is expected to broadly impact cancer metabolism.

Key Takeaways

The global cancer metabolism based therapeutics market is expected to witness high growth.

The North America region is currently dominating the market due to increasing investment in oncology research. Cancer metabolism based therapeutics represent a rapidly emerging field that the key players are focusing on in order to develop novel therapeutic strategies which address the unique metabolic alterations that cancer cells acquire.

Key players operating in the cancer metabolism based therapeutics market are Calithera Biosciences, Inc., Celgene Corporation, Agios Pharmaceutical, Rafael pharmaceuticals, and AstraZeneca. Calithera Biosciences has several clinical-stage small molecule inhibitors of glutaminase, which functions as a key enzyme in tumour glucose and glutamine metabolism. Celgene Corporation has several HIF-2α and IDH1/2 inhibitors in clinical trials targeting tumour metabolism. Agios Pharmaceutical has commercialized the IDH1 mutant inhibitor TIBSOVO® and is researching additional mutant IDH programs.

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